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Dempsey has also made notable appearances in the stage productions of On Golden Pond, with the Maine Acting Company, and as Timmy (the Martin Sheen role) in a 1990 Off-Broadway revival of The Subject Was Roses co-starring with John Mahoney and Dana Ivey at the Roundabout Theatre in New York.
Dempsey's first major feature film role was at age 21 with Beverly D'Angelo in the movie In The Mood, the true World War II story about Ellsworth Wisecarver whose relationships with older married women created a national uproar.
His success on the show has led to his becoming a spokesman for Mazda and State Farm Insurance. It's financially rewarding but there comes a point where how much is enough, really?
Prior to landing the role of Derek Shepherd, he auditioned for the role of Dr. Initially a mid-season replacement, Grey's Anatomy was well received and has become a highly rated program.
However, he received good reviews as he portrayed real-life mob boss, Meyer Lansky in 1991 when Mobsters was put on the screen.
His first major television role was a three-episode stint as Will Truman's closeted sportscaster boyfriend on Will & Grace.
In November 2008, he launched an Avon fragrance named Unscripted, and due to its success, a second fragrance named Patrick Dempsey 2 was launched in October 2009. It's all I think about on a daily basis." Dempsey, who maintains an extensive sports and vintage car collection, has enjoyed auto racing in his spare time for several years, and declared before the 24 Hours of Le Mans in 2013 that he would like to compete full-time, telling Eurosport: I would like to make that [motorsports] a complete priority and just focus on this full-time.
On September 29, 2012, Mexican cable company Cablemás, Megacable and Mexico city's Cablevisión launched an advertising campaign featuring Patrick Dempsey as the love interest of a domestic worker who comes across his profile on an online dating site. If I could just walk away from acting, I think I could do that very easily, and just focus on the driving, I would love that more than anything else.
Dempsey's most recent roles include the 2008 film Made of Honor as Tom and the 2010s romantic comedy Valentine's Day; the latter film follows five interconnecting stories about Los Angelinos anticipating (or in some cases dreading) the holiday of love.